8.02, 18.02

课程目的

生物学目前已探索分子层级系统，故对分子物理的需求正日益显著。在分子层级上了解生物系统的物理性质将使得我们可以设计操控这些生物系统。本课程是为主修生物工程的学生而开设之核心课程，讲授高等生物工程课程中所需之基础热力学与统计力学。这门课亦针对想对分子层次有所了解的机械工程系学生开启，作为主修机械而朝生物工程及纳米技术方向之部份课程。

此课程特别是针对生物系统物理化学的入门课程。且以统计力学来探讨巨观热力学性质与微观的分子性质之关联性，其包含化学与电化学位能、平衡态、在巨分子溶液与介面中的行为、巨分子的滴定及溶解现象。范例问题包含蛋白质结构、基因体分析、单分子生物力学及生医材料等。

演习

每周有二次一小时的演习，学生可以选择自己课表里头最方便的时间参加

教科书

Dill, K., 及 S. Bromberg共同著述之《分子级驱动力》(Molecular Driving Forces) New York: Garland Press, 2003. ISBN: 0815320515.

参考书籍

Hill, T. L.着《统计热力学简介》(An Introduction to Statistical Thermodynamics) New York: Dover, 1986. ISBN: 0486652424.

van Holde, K. E., W. C. Johnson及 P. S. Ho.共同著作之《物理生物化学原理》(Principles of Physical Biochemistry) Upper Saddle River, NJ: Prentice Hall, 1998. ISBN: 0137204590.

Eisenberg, D.及D. Crothers共同著作之《应用于生命科学的物理化学》(Physical Chemistry with Applications to the Life Sciences) Menlo Park, CA: Benjamin/Cummings, 1979. ISBN: 080532402X.

Kittel, C.及 H. Kroemer共同著作之《热物理》(Thermal Physics)第二版 San Francisco CA: W. H. Freeman, 1980. ISBN: 0716710889.

McQuarrie, D. A着《统计力学》(Statistical Mechanics) New York: Harper Collins, 1976.

Atkins, P. W.着《物理化学》(Physical Chemistry) San Francisco: W. H. Freeman, 1997.

评分

所有考试都不可以翻阅书籍，但可以携带一页笔记

家庭作业的原则

家庭作业不计算在学期成绩中，每周都会指定可能会在考试中出现的练习题并提供解答。在参考解答前请尝试自己解答这些问题且每周都做过所有练习题。练习题将会在演习课中讨论，通常不用看笔记或询问他人而可以轻易作答练习题的学生在考试中表现亦不错。

8.02, 18.02

Course Objectives

Biology is now probing molecular level systems, so the need for physical molecular are becoming prevalent. Understanding the physical properties of biological systems on the molecular level allows one to engineer them. This course was created for the development of a biological engineering major, and serves as a core course that teaches the fundamentals of thermodynamics and statistical mechanics necessary for upper level biological engineering courses. It is cross listed for mechanical engineers who wish to develop a molecular understanding, and serves as part of the bioengineering and nanotechnology tracks for mechanical engineering majors.

Specifically, this course serves as an introduction to the physical chemistry of biological systems and deals with the connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics. It includes chemical and electrochemical potentials, equilibrium states, the behavior of macromolecules in solution and at interfaces, titration of macromolecules, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.

Recitation

There will be two 1-hour recitation sections per week. Students may choose any one recitation section most convenient for their schedule.

Text

Dill, K., and S. Bromberg. Molecular Driving Forces. New York: Garland Press, 2003. ISBN: 0815320515.

Additional References

Hill, T. L. An Introduction to Statistical Thermodynamics. New York: Dover, 1986. ISBN: 0486652424.

van Holde, K. E., W. C. Johnson, and P. S. Ho. Principles of Physical Biochemistry. Upper Saddle River, NJ: Prentice Hall, 1998. ISBN: 0137204590.

Eisenberg, D., and D. Crothers. Physical Chemistry with Applications to the Life Sciences. Menlo Park, CA: Benjamin/Cummings, 1979. ISBN: 080532402X.

Kittel, C., and H. Kroemer. Thermal Physics. 2nd ed. San Francisco CA: W. H. Freeman, 1980. ISBN: 0716710889.

McQuarrie, D. A. Statistical Mechanics. New York: Harper Collins, 1976.

Atkins, P. W. Physical Chemistry. San Francisco: W. H. Freeman, 1997.

Grading

All examinations will be closed book. One page of notes is allowed.

Homework Policy

Homework will not be graded. Practice problems representative of those that will appear on exams will be assigned each week, along with solutions. Please attempt to work the homework on your own before looking at solutions and work all problems each week as they are assigned. Practice problems will be discussed in recitation sessions. Students who can work all practice problems easily without looking at notes or asking for help usually perform well on exams.

8.02, 18.02

Course Objectives

Biology is now probing molecular level systems, so the need for physical molecular are becoming prevalent. Understanding the physical properties of biological systems on the molecular level allows one to engineer them. This course was created for the development of a biological engineering major, and serves as a core course that teaches the fundamentals of thermodynamics and statistical mechanics necessary for upper level biological engineering courses. It is cross listed for mechanical engineers who wish to develop a molecular understanding, and serves as part of the bioengineering and nanotechnology tracks for mechanical engineering majors.

Specifically, this course serves as an introduction to the physical chemistry of biological systems and deals with the connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics. It includes chemical and electrochemical potentials, equilibrium states, the behavior of macromolecules in solution and at interfaces, titration of macromolecules, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.

Recitation

There will be two 1-hour recitation sections per week. Students may choose any one recitation section most convenient for their schedule.

Text

Dill, K., and S. Bromberg. Molecular Driving Forces. New York: Garland Press, 2003. ISBN: 0815320515.

Additional References

Hill, T. L. An Introduction to Statistical Thermodynamics. New York: Dover, 1986. ISBN: 0486652424.

van Holde, K. E., W. C. Johnson, and P. S. Ho. Principles of Physical Biochemistry. Upper Saddle River, NJ: Prentice Hall, 1998. ISBN: 0137204590.

Eisenberg, D., and D. Crothers. Physical Chemistry with Applications to the Life Sciences. Menlo Park, CA: Benjamin/Cummings, 1979. ISBN: 080532402X.

Kittel, C., and H. Kroemer. Thermal Physics. 2nd ed. San Francisco CA: W. H. Freeman, 1980. ISBN: 0716710889.

McQuarrie, D. A. Statistical Mechanics. New York: Harper Collins, 1976.

Atkins, P. W. Physical Chemistry. San Francisco: W. H. Freeman, 1997.

Grading

All examinations will be closed book. One page of notes is allowed.

Homework Policy

Homework will not be graded. Practice problems representative of those that will appear on exams will be assigned each week, along with solutions. Please attempt to work the homework on your own before looking at solutions and work all problems each week as they are assigned. Practice problems will be discussed in recitation sessions. Students who can work all practice problems easily without looking at notes or asking for help usually perform well on exams.

8.02, 18.02

Course Objectives

Biology is now probing molecular level systems, so the need for physical molecular are becoming prevalent. Understanding the physical properties of biological systems on the molecular level allows one to engineer them. This course was created for the development of a biological engineering major, and serves as a core course that teaches the fundamentals of thermodynamics and statistical mechanics necessary for upper level biological engineering courses. It is cross listed for mechanical engineers who wish to develop a molecular understanding, and serves as part of the bioengineering and nanotechnology tracks for mechanical engineering majors.

Specifically, this course serves as an introduction to the physical chemistry of biological systems and deals with the connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics. It includes chemical and electrochemical potentials, equilibrium states, the behavior of macromolecules in solution and at interfaces, titration of macromolecules, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.

Recitation

There will be two 1-hour recitation sections per week. Students may choose any one recitation section most convenient for their schedule.

Text

Dill, K., and S. Bromberg. Molecular Driving Forces. New York: Garland Press, 2003. ISBN: 0815320515.

Additional References

Hill, T. L. An Introduction to Statistical Thermodynamics. New York: Dover, 1986. ISBN: 0486652424.

van Holde, K. E., W. C. Johnson, and P. S. Ho. Principles of Physical Biochemistry. Upper Saddle River, NJ: Prentice Hall, 1998. ISBN: 0137204590.

Eisenberg, D., and D. Crothers. Physical Chemistry with Applications to the Life Sciences. Menlo Park, CA: Benjamin/Cummings, 1979. ISBN: 080532402X.

Kittel, C., and H. Kroemer. Thermal Physics. 2nd ed. San Francisco CA: W. H. Freeman, 1980. ISBN: 0716710889.

McQuarrie, D. A. Statistical Mechanics. New York: Harper Collins, 1976.

Atkins, P. W. Physical Chemistry. San Francisco: W. H. Freeman, 1997.

Grading

All examinations will be closed book. One page of notes is allowed.

Homework Policy

Homework will not be graded. Practice problems representative of those that will appear on exams will be assigned each week, along with solutions. Please attempt to work the homework on your own before looking at solutions and work all problems each week as they are assigned. Practice problems will be discussed in recitation sessions. Students who can work all practice problems easily without looking at notes or asking for help usually perform well on exams.